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Kensei Tobinai Selected Research

Non-Hodgkin Lymphoma (Lymphosarcoma)

9/2022Oral histone deacetylase inhibitor HBI-8000 (tucidinostat) in Japanese patients with relapsed or refractory non-Hodgkin's lymphoma: phase I safety and efficacy.
6/2021CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib.
1/2021Safety and pharmacokinetics of polatuzumab vedotin in Japanese patients with relapsed/refractory B-cell non-Hodgkin lymphoma: a phase 1 dose-escalation study.
12/2020Phase 1b study to investigate the safety and tolerability of idelalisib in Japanese patients with relapsed/refractory follicular lymphoma and chronic lymphocytic leukemia.
9/2020Safety considerations with targeted therapy drugs for B-cell non-Hodgkin lymphoma.
1/2020A phase 3 randomized study (HOMER) of ofatumumab vs rituximab in iNHL relapsed after rituximab-containing therapy.
10/2019Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy.
5/2019Phase I study of tirabrutinib (ONO-4059/GS-4059) in patients with relapsed or refractory B-cell malignancies in Japan.
1/2019Chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma: opportunities and challenges.
8/2018Safety, tolerability and pharmacokinetics of shorter duration of infusion of obinutuzumab in Japanese patients with B-cell non-Hodgkin lymphoma: final results of the phase II GATS study.
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Kensei Tobinai Research Topics

Disease

59Lymphoma (Lymphomas)
10/2022 - 01/2002
53Non-Hodgkin Lymphoma (Lymphosarcoma)
09/2022 - 12/2002
46Neoplasms (Cancer)
09/2022 - 01/2002
27B-Cell Lymphoma (Lymphoma, B Cell)
01/2022 - 01/2002
21Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
02/2021 - 05/2004
20Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2021 - 08/2003
19Peripheral T-Cell Lymphoma (Lymphoma, T Cell, Peripheral)
10/2022 - 03/2010
19Multiple Myeloma
12/2021 - 10/2007
18Infections
11/2019 - 03/2002
17Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
06/2021 - 12/2002
16Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
08/2022 - 02/2003
15Neutropenia
02/2021 - 02/2002
13Hodgkin Disease (Hodgkin's Disease)
04/2021 - 02/2003
12Disease Progression
12/2020 - 02/2003
11Thrombocytopenia (Thrombopenia)
02/2021 - 12/2007
10Lymphopenia (Lymphocytopenia)
06/2021 - 08/2010
10T-Cell Lymphoma (Lymphoma, T Cell)
01/2020 - 12/2002
8Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma)
10/2022 - 05/2011
8Pneumonia (Pneumonitis)
12/2021 - 02/2003
8B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
03/2021 - 01/2009
8Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
01/2018 - 06/2003
7Hematologic Neoplasms (Hematological Malignancy)
11/2016 - 04/2002
6Graft vs Host Disease (Graft-Versus-Host Disease)
10/2017 - 03/2002
6Anemia
01/2016 - 10/2006
5Fever (Fevers)
06/2021 - 11/2008
5Leukopenia
12/2016 - 08/2010
4Myelodysplastic Syndromes (Myelodysplastic Syndrome)
04/2017 - 08/2007
4Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2016 - 09/2007
3Diarrhea
12/2020 - 10/2004
3Hepatitis
10/2019 - 12/2014
3Marginal Zone B-Cell Lymphoma (MALT Lymphoma)
07/2019 - 07/2004
3Exanthema (Rash)
03/2018 - 01/2016
3Fatigue
03/2018 - 10/2006
3Sepsis (Septicemia)
01/2018 - 02/2003
3Nausea
11/2016 - 08/2010
3Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
10/2011 - 07/2007
3Anorexia
04/2011 - 01/2010
3Leukemia
09/2010 - 04/2002
2Hypoalbuminemia
06/2021 - 03/2018

Drug/Important Bio-Agent (IBA)

53Rituximab (Mabthera)FDA Link
03/2021 - 01/2002
23Vincristine (Oncovin)FDA LinkGeneric
10/2022 - 02/2003
22Doxorubicin (Adriamycin)FDA LinkGeneric
10/2022 - 02/2003
22Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2022 - 08/2003
22Monoclonal AntibodiesIBA
10/2020 - 01/2002
14Prednisolone (Predate)FDA LinkGeneric
01/2021 - 02/2003
12mogamulizumabIBA
08/2022 - 03/2010
11Bortezomib (Velcade)FDA Link
12/2021 - 06/2007
10Prednisone (Sone)FDA LinkGeneric
10/2022 - 06/2005
9Dexamethasone (Maxidex)FDA LinkGeneric
06/2021 - 04/2011
9Bendamustine HydrochlorideFDA Link
10/2018 - 09/2010
8Brentuximab VedotinIBA
04/2021 - 07/2014
8Pharmaceutical PreparationsIBA
02/2021 - 02/2007
7CladribineFDA LinkGeneric
07/2009 - 04/2002
6obinutuzumabIBA
10/2019 - 01/2013
6CCR4 ReceptorsIBA
05/2019 - 03/2012
6Granulocyte Colony-Stimulating Factor (G-CSF)IBA
11/2018 - 02/2002
5Etoposide (VP 16)FDA LinkGeneric
12/2020 - 02/2003
5Lenalidomide (CC 5013)FDA Link
11/2020 - 03/2016
5Immunoconjugates (Immunoconjugate)IBA
09/2020 - 09/2002
5AntibodiesIBA
09/2020 - 08/2003
5VorinostatFDA Link
01/2018 - 01/2010
4Histone Deacetylase InhibitorsIBA
09/2022 - 01/2010
4Biomarkers (Surrogate Marker)IBA
12/2021 - 05/2008
4Transaminases (Aminotransferases)IBA
06/2021 - 11/2010
4ibrutinibIBA
06/2021 - 01/2016
4Adenosine Monophosphate (AMP)IBA
12/2020 - 12/2007
410-propargyl-10-deazaaminopterinFDA Link
01/2020 - 04/2010
4DNA (Deoxyribonucleic Acid)IBA
10/2019 - 05/2004
4carfilzomibIBA
09/2019 - 03/2016
4forodesineIBA
01/2019 - 07/2012
4Proteins (Proteins, Gene)FDA Link
02/2018 - 02/2005
4Inotuzumab OzogamicinIBA
01/2018 - 08/2010
4CalicheamicinsIBA
10/2016 - 05/2009
3pomalidomideIBA
06/2021 - 01/2015
3fludarabineIBA
03/2021 - 07/2004
3NivolumabIBA
10/2020 - 03/2017
3Agammaglobulinaemia Tyrosine KinaseIBA
09/2020 - 01/2016
3GalliumIBA
10/2019 - 10/2018
3Anti-Bacterial Agents (Antibiotics)IBA
07/2019 - 08/2010
3Alanine Transaminase (SGPT)IBA
03/2018 - 10/2004
3Anaplastic Lymphoma KinaseIBA
02/2018 - 07/2012
3Biological ProductsIBA
11/2017 - 03/2014
3Melphalan (Alkeran)FDA LinkGeneric
01/2016 - 04/2011
3Proteasome InhibitorsIBA
01/2008 - 06/2007
3ibritumomab tiuxetan (Zevalin)FDA Link
01/2007 - 10/2002
2Histone Deacetylases (Histone Deacetylase)IBA
09/2022 - 10/2012
2Cyclin D1IBA
06/2021 - 01/2002
2pembrolizumabIBA
06/2021 - 11/2020
2Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
02/2021 - 02/2015

Therapy/Procedure

57Therapeutics
10/2022 - 03/2002
49Drug Therapy (Chemotherapy)
08/2022 - 12/2002
14Stem Cell Transplantation
10/2020 - 04/2002
13Hematopoietic Stem Cell Transplantation
04/2022 - 07/2006
8Radioimmunotherapy
01/2009 - 10/2002
7Transplantation
01/2018 - 07/2002
5Radiotherapy
02/2021 - 06/2005
5Chemoradiotherapy
01/2018 - 02/2006
5Combination Drug Therapy (Combination Chemotherapy)
04/2016 - 02/2003
3Cell Transplantation
01/2018 - 08/2007
3Homologous Transplantation
01/2018 - 04/2002